主要研究方向及展望:

我们自主研发了多种新型高时空分辨超快二维红外光谱原位检测技术：

这种技术不仅具备了传统一维光谱对分子官能团或化学键本征振动模式的表征功能，更可独特地直接检测分子内和分子间相互作用的动力学信息，以及分子结构变化动力学与基态和激发态的关联性，可高时空分辨地预测分子在非平衡态（激发态）的三维空间结构和分子反应中间体，从而更准确、详细和高灵敏地探测分子在平衡态或非平衡态（激发态）结构变化动力学路径。

利用此技术，我们在分子水平挑战性地对分子间和分子内的弱氢键相互作用在生物蛋白功能结构,酶活性,光（或电）催化化学反应,药物与蛋白相互作用以及能源材料分子发光机理等方面的能动调控动力学进行超高时空的原位微观研究。

利用自主研发的二维红外超快光谱系统，通过对分子本征振动模式以及分子内或分子间相互作用动力学的直接测量，对不同体系的分子三维功能结构以及相应结构变化动力学进行高时空分辨研究。

本实验室在分子水平从事以下几个方向的研究：

1.蛋白质分子动态功能结构的高时空分辨研究；

2.纳米药物和中药的靶向性和有效性；

3.癌症疾病的高灵敏度探测；

4.蛋白质分子结构畸变与疾病；

5.生物酶催化与在药物中的应用；

6.生物分子开关与纳米功能材料；

7.发光材料与能源材料的微观机理。

8.量子材料与器件的超快载流子动力学研究。

过去的主要工作及获得的成果:

针对传统一维光谱对分子结构和动力学行为探测的局限性和不确定性，运用多种多维超快光谱技术(包括二维五级拉曼光谱，二维红外光谱，二维瞬态红外光谱,二维拉曼受激辐射光谱)在分子水平和超快时间范围（飞秒—皮秒）对分子功能结构，分子内和分子间的相互作用动力学进行超高时空分辨的微观研究。

已发表SCI（包括JACS, AngewChem.Int.Ed, Adv. Mater.）科研论文50余篇，被他引千余次。

培养研究生情况:

已培养多名硕博生。欢迎具有不同学科（物理、化学或生物）背景的学生加入。

也欢迎即将毕业的博士生进行博后申请。

代表性论文及专利:

[1] M. Werkmeister, Yun-Liang LI , E. B. Lerch, Damien Bigouar, J, Bredenbeck, Ultrafast Hopping from Band to Band: Assigning Infrared Spectra based on Vibrational Energy Transfer, Angew. Chem.Int. Ed. 52, 1-5 (2013).

[2] Lili Du,Xiting Zhang, Jiadan Xue, WenJian Tang, Ming-De Li, Xin Lan,Jiangrui Zhu,Ruixue Zhu, Yuxiang Weng Yun-Liang Li,*,and David Lee Phillips*, Influence of Water in the Photogeneration and Properties of a Bifunctional Quinone Methide, J. Phys. Chem. B 120 ,43(2016).

[3] Zhang jia,Wang li,Zhang jin,Zhu jiang rui, Pan xin,Wang jiangyun*,Fang weihai*,Li yunliang*,Identifying and modulating accidental fermi resonance: 2D IR and DFT study of 4-azido-l-phenylalanine, J.Phys.Chem.B, 122 (34) :8122-8133(2019).

[4] Wangwei Chen, Juanjuan Qi,Chao Dong, iuyuan Zhao, Junwei Chen, Shangfeng Yang, Tao Chen, Chong Chen*, Yunliang Li*, Ming De Li *, Mingtai Wang*, Solution-processed in-situ growth of CuInS2 nanoparticle films for efficient planar heterojunction solar cells with a dual nature of chargegeneration, ACS Applied Energy Materials, 2:5231-5232(2019).

[5] Kang Wang, Yujun Xie, Ming Liu, Wei Tao, Hao Zhang, Meidong Huang, Jinmao You,Ying Liu, Yunliang Li,* Zhen Li,* and Yong Qiang Dong* High-Contrast Polymorphic Luminogen Formed through Effect of Tiny Differences in Intermolecular Interactions on the Intramolecular Charge Transfer Process,Adv.Optical.Mater.,2000436(1-10)(2020).

[6] Qingxin Guo, Yahui Liu, Ming Liu,Hao Zhang, Xiquan Qian; Jinjin Yang; Jing Wang, Wenyue Xue; QianZhao,Xinjun Xu*, Wei Ma, Zheng Tang, Yunliang Li*, Zhishan Bo*, Enhancing the Performance of Organic Solar Cells by Prolonging the Lifetime of Photogenerated Excitons. Advanced materials, 2003164(1-10)(2020).

[7] Li Wang,Jia Zhang,Ming-Jie Han, Lu Zhang, Chao Chen, Aiping Huang, Ruipei Xie, Guosheng Wang, Jiangrui Zhu, Yuchuan Wang, Xiaohong Liu*, Wei Zhuang*, Yunliang Li*, Jiangyun Wang*,A genetically encoded two dimensional infrared probe for enzyme active-site dynamics,Angew.Chem.Int.Ed. (2021).

[8] Jiangrui Zhu, Juanjuang Wang, Guosheng Wang, Jia Zhang, Wei Tao, Chang Liu, Ming Liu, Hao Zhang,Ruipei Xie, Fangfu Ye, Ying Liu, Weihai Fang,*Xuebo Chen,* and Yunliang Li* Precise Identification of the Dimethyl Sulfoxide Triggered Tricarbonyldichlororuthenium(II) Dimer for Releasing CO. J.Phys.Chem.Lett. ,12, 4658−4665(2021).

[9] Liangliang Wu, Yu Fang, Wanlong Zuo, Juanjuan Wang, Ju Wang, Shufeng Wang, Zhifeng Cui,Weihai Fang, Hao-Ling Sun*, Yunliang Li*,and Xuebo Chen*, Excited-State Dynamics of Crossing-Controlled Energy Transfer in Europium Complexes,JACS Au 2, 4, 853–864(2022).

[10] Yihong Gao, Hongxiong Liu,Fengxia Hu*,Hongyan Song,Hao Zhang,Jiazheng Hao, Xingzheng Liu,Zibing Yu,Feiran Shen,Yangxin Wang,Houbo Zhou,Bingjie Wang,Zhengying Tian,Yuan Lin,Cheng Zhang,Zhuo Yin,Jing Wang*,Yunzhong Chen,Yunliang Li*,Youting Song,Youguo Shi,Tongyun Zhao,Jirong Sun,Qingzhen Huang，Baogen Shen*，Reversible colossal barocaloric effect dominated by disordering of organic chains in (CH3–(CH2)n−1 –NH3)2MnCl4 single crystals，NPG Asia Materials14:34(2022).

[11] Zibing Yu, Houbo Zhou, Fengxia Hu*, Chang Liu, Shuaikang Yuan, Donghui Wang, Jiazheng Hao, Yihong Gao, Yangxin Wang, Bingjie Wang, Zhengying Tian, Yuan Lin, Cheng Zhang, Zhuo Yin, Jing Wang*, Yunzhong Chen, Yunliang Li*, Jirong Sun, Tongyun Zhao & Baogen Shen* ，Colossal barocaloric effect achieved by exploiting the amorphous high entropy of solidified polyethylene glycol，NPG Asia Materials 14:96(2022).

[12] Shuting Wang，Jianshu Gao，Fuqi Lu,Fang Wang,Zhongyuan You，Meidong Huang , Weihai Fang* ，Xiufeng Liu* ，Yunliang Li*, Ying Liu *，Human motion recognition by a shoes-floor triboelectric nanogenerator and its application in fall detection ,Nano Energy,108,108230(2023).

[13] Shunye Gao et al., Discovery of a single-band Mott insulator in a van der Waals flat-band compound，Physical Review X 13, 041049 (2023).

[14] L Zhang, etc, Multi-Component Lithiophilic Alloy Film Modified Cu Current Collector for Long-Life Lithium Metal Batteries by a Novel FCVA Co-Deposition System,Small,202402752(1-12),(2024)

[15] LH Li, etc, Cholic acid tuning the binary surfactant system for one-step separation of the enantiomers of (5, 4) carbon nanotubes,Carbon, 222,119000,(2024).

[16] Xiao Li, et al., Order of magnitude improvement in the transport performance of carbon nanotube films by completely removing surfactants, Carbon,218,118750,(2024).

[17] Xinyi Xue, et al., Giant Photon-drag-induced Ultrafast Photocurrent in Diamond for Nonlinear Photonics, Laser & Photonics Reviews,2301146(1-10) (2024).

[18] Gao, YH, et al.,Low pressure reversibly driving colossal barocaloric effect in two-dimensional vdW alkylammonium halides, Nat Commun 15, 1838 (2024).

[19] DH Wang, etc,,Strain and Electron Doping-Induced In-Plane Spin Orientation at Room Temperature in Single-Layer CrTe2, ACS Appl. Mater. Interfaces 16(22), 28791–28797(2024).

[20] Xu CH, et al., Sodium Ion-Induced Structural Transition on the Surface of a DNA-Interacting Protein,Advanced Sciences,https://doi.org/10.1002/advs.202401838,(2024).

专利：

Zhang jia; Zhu jiangrui; Li gang; Li yunliang*; 中红外光谱的室温多通道可见光探测器全谱测量，2017-11-1,中国，201711155568.0.